Octanol pka

CHAPTER 4. CHEMICAL AND PHYSICAL INFORMATION

CHAPTER 4. CHEMICAL AND PHYSICAL INFORMATION 4.1 CHEMICAL IDENTITY Information regarding the chemical identity of perfluoroalkyls is located in Table 4-1. This information includes synonyms, chemical formulas and structures, and identification numbers. The perfluoroalkyls

September 12th,2019

Clinical Pharmacokinetics of Cannabinoids

n-octanol/water partition coefficient (K ow)of∆9-THC at neutral pH vary between 6,000 using shake-flask methodology (Mechoulam et al. 1981) and 9,440,000 by reverse-phase high-pressure liquid chromatographic es-timation (Thomas et al. 1990). The wide range for aqueous solubility and K ow

September 12th,2019

THE OCTANOL-WATER PARTITION CONSTANT

THE OCTANOL-WATER PARTITION CONSTANT: K ow. The distribution of nonpolar organic compounds between water and natural solids (e.g., soils, sediments and suspended particles) or organisms, can be viewed in many cases as a partitioning process

September 12th,2019

Apparent octanol/water partition coefficients of ...

octanol were tested in duplicate, In general, the duplicate measurements were within 5% of each other. Over the entire pH range, the apparent ... ionization of this weak acid (pKa 4.8). At pH ~9, another strong decrease of log PAP, is found for a relatively small increase in the pH. The cause of

September 12th,2019

Calculate reagent log P values to - Thermo Fisher Scientific

water vs. a simple organic compound like octanol or hexane can provide a guideline for predicting its solubility characteristics in other aqueous and organic solvents. For example, a peptide with a measured log P equal to 1 indicates that its concentration is at a 10:1 ratio in organic to aqueous phase.

September 12th,2019

1-Octanol (O4500) - Product Information Sheet - Sigma-Aldrich

1-Octanol has been used as a solvent for synthesis in biphasic solvents, such as in the bioproduction of 3-methylcatechol.2 1-Octanol is commonly utilized in biphasic systems with water to study the partitioning of compounds between organic and aqueous solution phases.3,4,5 A report on the use of 1-octanol in phase transfer and

September 12th,2019

pKa and log P - cyprotex.com

is dissolved in a two-phase water-octanol system, and titrated over a pH range (typically 2 to 12 for bases and ampholytes, 12 to 2 for acids). Although the solution becomes opaque during stirring, the pH electrode continues to measure pH of the aqueous component of the solution. Results are obtained by a complex computational process.

September 12th,2019

Lipophilicity Descriptors: Understanding When to Use LogP ...

octanol [Compound] [Compound] P Note LogP = 1 means there is a 10:1 ratio Organic:Aqueous For ionizable solutes, the compound may exist as a variety of different species in each phase at any given pH. D, the distribution coefficient, is the appropriate descriptor for ionizable compounds since it is

September 12th,2019

Determination of Log P for Compounds of Different Polarity ...

and octanol, is frequently used in the pharmaceutical industry to evaluate the lipophilicity of a compound. Especially if the distribution between the water and the octanol phase is significantly different, the linear range of the detector must be extremely wide, or the applied injection volumes have to be adjusted.

September 12th,2019

CHAPTER 4. CHEMICAL AND PHYSICAL INFORMATION

CHAPTER 4. CHEMICAL AND PHYSICAL INFORMATION 4.1 CHEMICAL IDENTITY Information regarding the chemical identity of perfluoroalkyls is located in Table 4-1. This information includes synonyms, chemical formulas and structures, and identification numbers. The perfluoroalkyls